Tiredness has become so normalised it is almost a personality trait. But persistent fatigue, particularly in women, is one of the most common early signs of one of the most under-diagnosed deficiencies in the world.
Anaemia affects around one in three women globally, and iron deficiency is one of the leading contributors. Closer to home, a South African review found that between 1997 and 2021, anaemia prevalence in women of reproductive age ranged from 22% to 44%, while iron deficiency ranged from 7.7% to 19%.
Yet most cases go undetected because the symptoms develop slowly, testing is not always comprehensive, and some laboratory cut-offs may not yet reflect newer guidance around earlier-stage deficiency.
1 in 3
Women globally are affected by anaemia
44%
Peak anaemia prevalence in SA women of reproductive age (1997–2021)
We talk about fatigue, joke about it, push through it — and rarely stop to ask what it is actually telling us.
Symptom checker
Before we go into the stages of iron deficiency, risks and testing — here is a symptom guide to help you recognise what to look for.
Important: This checklist is for informational purposes only and does not constitute medical advice or a diagnosis. Please consult a qualified healthcare practitioner before starting any supplementation.
Signs and symptoms to look for
Energy and cognition
- Persistent fatigue, especially that mid-afternoon wall
- Brain fog and poor concentration
- Reduced exercise tolerance — things that used to feel easy suddenly don't
- Light-headedness or dizziness on standing
Hair, skin and nails
- Increased hair shedding, particularly around the temples and parting
- Brittle, ridged or spoon-shaped nails (koilonychia)
- Dry, pale and dull complexion that no amount of moisturiser quite fixes
- Cracks at the corners of the mouth (angular cheilitis)
- Pale lower inner eyelids
Heart, breath and circulation
- Shortness of breath on stairs or hills that never used to feel hard
- Heart palpitations or a noticeably faster heartbeat at rest
- Cold hands and feet, even when the rest of you feels warm
Mood, sleep and nervous system
- Restless legs at night or that uncomfortable urge to move them just as you settle
- Anxiety, irritability or low mood without an obvious cause
- Poor sleep quality — waking unrefreshed despite the hours
Less well-known signs
- Cravings for ice (pagophagia) or non-food items like soil or clay (pica)
- A smooth, sore or unusually red tongue (atrophic glossitis)
- More frequent colds and infections than usual
- Difficulty regulating body temperature
There are three stages, not one
Most people think of iron deficiency as something you either have or don't. But iron deficiency develops in three distinct stages — and most of us never hear about the first two.
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Stage1
Depleted iron stores
The body's iron reserves (stored as ferritin) are running low, but blood iron and haemoglobin still look normal on a standard full blood count. Symptoms — particularly fatigue, hair shedding, poor concentration and reduced exercise tolerance — can already begin here. Most lab reports will still print "normal" at this stage.
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Stage2
Iron deficiency without anaemia (IDWA)
Iron stores are low and circulating iron may be reduced, but haemoglobin has not yet dropped below the anaemia range. Symptoms can become more noticeable here — even though a person may not yet be classified as anaemic.
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Stage3
Iron deficiency anaemia (IDA)
Haemoglobin has dropped below the normal range and the body cannot produce enough healthy, oxygen-carrying red blood cells. This is the most severe stage and the one most healthcare systems still focus on for diagnosis. By the time you reach it, you have usually been deficient for months or even years.
Who is at higher risk?
- Menstruating women. Heavy periods (menorrhagia) are one of the most common causes of iron deficiency in women under 50.
- Pregnant and postpartum women. Iron needs nearly double in pregnancy as the body builds blood volume for two.
- Plant-based eaters. Iron from plant foods (non-haem iron) is less bioavailable than iron from animal foods, and compounds like phytates, polyphenols and tannins can reduce absorption further.
- Athletes and endurance trainers. Higher demands, increased losses through sweat and foot-strike haemolysis all deplete iron stores faster.
- Women with PMOS (formerly PCOS) or endometriosis due to chronic blood loss and hormonal factors.
- People with low stomach acid or on PPIs. Stomach acid is essential for converting dietary iron to its absorbable form. Long-term acid-suppressing medications — and age-related decline in stomach acid — can reduce iron uptake significantly.
- People with gut inflammation. Coeliac disease, inflammatory bowel disease and other gut conditions that affect absorption increase the risk.
- Anyone with hidden blood loss. Haemorrhoids, ulcers and undiagnosed digestive bleeding can quietly deplete iron over months without obvious symptoms.
How to test for iron deficiency
If you suspect you might be low in iron, please see your doctor and request a blood test. The most useful is a full iron panel (sometimes called iron studies) — not just a haemoglobin or full blood count alone.
A full iron panel usually includes:
- Ferritin — the storage form of iron. This gives the earliest warning of deficiency and is the most important single marker to request.
- Serum iron — the iron currently circulating in your blood. Highly variable hour to hour, so should always be interpreted alongside the others.
- Transferrin saturation (TSAT) — the percentage of your iron-transport protein actually carrying iron. A TSAT below 20% is strongly suggestive of iron deficiency.
- Full blood count (FBC) — particularly haemoglobin (Hb) and mean corpuscular volume (MCV). A low MCV is a classic finding in iron deficiency anaemia.
- C-reactive protein (CRP) — a measure of inflammation. If ferritin looks "normal" but CRP is elevated, your true iron stores may be considerably lower than the number suggests.
- Total iron binding capacity (TIBC) — how much iron your blood is capable of carrying. Typically rises when iron stores are low.
- Haematocrit (PCV) — the percentage of your blood volume made up by red blood cells. Lower than normal indicates anaemia.
Why ferritin alone is not always enough
Ferritin is an "acute-phase reactant" — it rises in response to inflammation, infection, liver issues, alcohol intake, obesity and even strenuous exercise. Someone who is genuinely iron-deficient can show a perfectly normal ferritin number if there is background inflammation.
For many years, the standard cut-off for iron deficiency was a ferritin below 12–15 µg/L. Many labs have since updated their lower reference range to 30 µg/L, and the American Society of Hematology moved in the same direction in its 2025 draft recommendations — particularly for menstruating and pregnant individuals.
If your ferritin comes back in the 15–30 µg/L range and your doctor says your iron is fine, it is reasonable to ask whether the newer thresholds are being applied — particularly if you are symptomatic.
The South African picture
A 2025 Cape Town birth cohort study found that iron deficiency may be far more common than standard blood tests suggest. When researchers adjusted ferritin for inflammation, iron deficiency estimates rose to as high as 55% in pregnant women and 47% in postnatal women. The numbers varied depending on the method used, but the takeaway was clear: in South African women, iron deficiency is easy to miss.
A note on self-supplementing
If you recognise yourself in several of the signs above, please do not start a high-dose iron supplement before testing. There are two important reasons.
First: some people have iron overload conditions (such as haemochromatosis) where additional iron is harmful. Without testing, you cannot know which side of the line you are on.
Second: many symptoms of iron deficiency overlap with other conditions — thyroid issues, B12 deficiency, vitamin D deficiency, sleep disorders and depression. Testing helps make sure you are addressing the right thing.
We've written a follow-up piece on how iron actually works in the body, why the form of iron matters so much, and what to look for in a well-formulated supplement.
This article is for educational purposes only and is not intended to diagnose, treat or replace medical advice. Iron deficiency, like all health concerns, should be assessed and managed in consultation with a qualified healthcare practitioner. Please do not begin iron supplementation without prior testing.
References
- Ringshaw JE, Zieff MR, Williams S, et al. Iron deficiency anaemia in mothers and infants with high inflammatory burden: Prevalence and profile in a South African birth cohort. PLOS Global Public Health. 2025;5(7). Link
- Turawa E, Awotiwon O, Dhansay MA, et al. Prevalence of Anaemia, Iron Deficiency, and Iron Deficiency Anaemia in Women of Reproductive Age and Children under 5 Years of Age in South Africa (1997–2021). Int J Environ Res Public Health. 2021;18(23):12799. Link
- An audit of the iron status of patients at Chris Hani Baragwanath Academic Hospital, Johannesburg. 2024. Link
- British Society for Haematology. Identification and management of preoperative anaemia in adults. Br J Haematol. 2024;205(1):88–99. Link
- Rethinking ferritin thresholds: towards a physiological-based definition of iron deficiency. The Lancet Global Health. 2025. Link






